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Randomized Controlled Trial Comparative Study Clinical Trial
Oral lormetazepam in premedication. A comparison with diazepam.
- C J Jakobsen, J J Jensen, W Hansen, and N Grabe.
- Anaesthesia. 1986 Aug 1;41(8):870-3.
AbstractLormetazepam, a relatively new benzodiazepine was compared in a randomised, double blind trial with diazepam for its effectiveness as an oral premedicant drug. A scoring system was used to assess sedation, relief of anxiety, nausea, dizziness and cardiovascular effects in two groups of patients having orthopaedic operations. Some statistical indication that lormetazepam has a greater anxiolytic effect than diazepam was found, but in assessing total effect using a known scoring system, no difference was demonstrated between the two drugs.
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