• Respiratory care · Sep 2014

    Review Case Reports

    Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.

    • Chiara Giraudo, Nazarena Nannini, Elisabetta Balestro, Alessia Meneghin, Francesca Lunardi, Roberta Polverosi, and Fiorella Calabrese.
    • Department of Radiology, Venetian Oncology Institute, Padua, Italy.
    • Respir Care. 2014 Sep 1;59(9):e132-6.

    AbstractWe report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a surgical lung biopsy and by excluding other causes of granulomatous disease. In paucisymptomatic/asymptomatic patients, as in our case, therapy is not necessary, with a good prognosis and complete recovery. NSG is a rare systemic disease similar to sarcoidosis and Wegener's granulomatosis with a benign clinical course and should always be considered for patients with nodular pulmonary lesions even with subclinical or uncommon features.Copyright © 2014 by Daedalus Enterprises.

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