• Vilma Savy, Agustín Ciapponi, Ariel Bardach, Demián Glujovsky, Patricia Aruj, Agustina Mazzoni, Luz Gibbons, Eduardo Ortega-Barría, and Rómulo E Colindres.
• Instituto Nacional de Enfermedades Infecciosas, ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, ArgentinaGlaxoSmithKline Biologicals, Rio de Janeiro, Brazil.
• Influenza Other Respi Viruses. 2013 Nov 1;7(6):1017-32.

ObjectiveInfluenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean.DesignMeta-analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta-analyses.SettingA literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts.SampleWe identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET.Main Outcome MeasuresIncidence, percentage of influenza specimens out of the total received by influenza centers and resource-use outcomes.ResultsA total of 483 130 specimens of patients with influenza were analyzed. Meta-analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza-like illness per 100 000 persons-years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza-like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory-confirmed influenza case.ConclusionsOur data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine-uptake rate has been low in this region. Population-based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making.© 2012 John Wiley & Sons Ltd.

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