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Arzneimittel Forsch · Jan 1980
On some properties of a new steroid curare-like compound pipecurium bromide.
- R N Alyautdin, V V Buyanov, V P Fisenko, E J Lemina, V K Muratov, D N Samoilov, and V A Shorr.
- Arzneimittel Forsch. 1980 Jan 1;30(2a):355-7.
AbstractIn experiments on cats it has been shown that 2 beta, 16 beta-bis (4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan), is a non-depolarizing muscular blocker. The order of myorelaxation evoked by this agent is characteristic: first the chewing and limb muscles, then abdominal muscles and diaphragm and at the end intercostal muscles are relaxed. Pipercurium bromide has no cardiotropic, atropine-like, or ganglion-blocking activity. It fails to influence the coronary blood-supply or myocardial oxygen consumption. No acetylcholinesterase inhibiting action of the compound was seen. It does not affect the central nervous system.
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