• Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · May 2007

    [Analysis of Foxp3+ CD4+ CD25+ regulatory cells in peripheral blood of patients with SLE].

    • Hong-gang Wei, Bei Cai, Lan-lan Wang, Jia Li, and Wei-hua Feng.
    • Clinical Immunological Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China.
    • Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 May 1;23(5):432-5.

    AimTo investigate the expression of GITR on T cells and the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells in the peripheral blood of patients with SLE.MethodsThe expression of GITR and Foxp3(+) CD4(+) CD25(+) regulatory T cells in the peripheral blood was determined by flow cytometry(FCM).ResultsCompared with health control, the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells in peripheral blood from SLE patients was lower (P<0.05), but there is no difference in the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells between active and inactive SLE patients (P>0.05). GITR expression on both CD3(+) CD4(+) T cells and CD3(+) CD8(+) T cells of SLE patients increased significantly (P>0.05). With the development of SLE activity, GITR expression didn't change significantly on both CD3(+) CD4(+) T cells (P>0.05) and CD3(+) CD8(+) T cells (P>0.05).ConclusionThe expression abnormality of both Foxp3(+) CD4(+) CD25(+) regulatory cells and GITR may play important role in the imbalance of immune homeostasis in SLE.

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