• Anna Finnemore, Hilary Toulmin, Naz Merchant, Tom Arichi, Nora Tusor, David Cox, Ash Ederies, Phumza Nongena, Christopher Ko, Ryan Dias, Anthony D Edwards, and Alan M Groves.
• Centre for the Developing Brain, Imperial College London and MRC Clinical Sciences Centre, London, UK.
• Paediatr Anaesth. 2014 Feb 1; 24 (2): 190195190-5.

BackgroundThe aim of this study was to look for clinically significant adverse effects of chloral hydrate used in a large cohort of infants sedated for magnetic resonance imaging.MethodCase notes of infants who underwent magnetic resonance imaging (MRI) scanning from 2008 to 2010 were reviewed, with patient demographics, sedation dose, comorbidities, time to discharge, and side effects of sedation noted.ResultsFour hundred and eleven infants (median [range] postmenstrual age per weight at scan 42 [31(+4) -60] weeks per 3500 g [1060-9900 g]) were sedated with chloral hydrate (median [range] dose 50 [20-80] mg·kg(-1)). In three cases (0.7%), desaturations occurred which prompted termination of the scan. One infant (0.2%) was admitted for additional observation following sedation but had no prolonged effects. In 17 (3.1%) cases, infants had desaturations which were self-limiting or responded to additional inspired oxygen such that scanning was allowed to continue.ConclusionWhen adhering to strict protocols, MRI scanning in newborn infants in this cohort was performed using chloral hydrate sedation with a relatively low risk of significant adverse effects.© 2013 John Wiley & Sons Ltd.

22 keywords...

hide…