• Pediatric radiology · Feb 2008

    Case Reports

    Severe cerebellitis following methadone poisoning.

    • Fionnghuala Mills, Suzanna C MacLennan, Catherine J Devile, and Dawn E Saunders.
    • Department of Paediatric Neurology, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 1EH, UK. fionnghualamills@doctors.org.uk
    • Pediatr Radiol. 2008 Feb 1;38(2):227-9.

    AbstractWe report a 3-year-old girl with an unusual presentation of cerebellitis following ingestion of methadone. CT showed diffuse symmetrical swelling and oedema of the cerebellum resulting in compression of the fourth ventricle and hydrocephalus. The changes were confirmed on MRI with the addition of watershed injuries. These findings represent a toxic encephalopathy and have been reported in previous cases of heroin intoxication by inhalation, but rarely following opioid ingestion. The aetiology of the watershed infarcts is discussed.

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