• C De Deyne, M Struys, R Heylen, R De Jongh, M Van der Laenen, L Buyse, J Deghislage, and G Rolly.
• Department of Anesthesia and Critical Care Medicine, Ziekenhuis Oost-Limburg, Campus Sint-Jan, Genk, Belgium.
• J Clin Anesth. 2000 Feb 1;12(1):52-7.

Study ObjectiveTo assess the anesthetic effects of clonidine during sevoflurane anesthesia guided by the bispectral index (BIS), which is a processed EEG variable correlated with anesthetic-hypnotic depth.DesignPlacebo-controlled, double-blind clinical trial.SettingsElective laparoscopic surgery.Patients60 ASA physical status I patients scheduled for laparoscopic surgery.InterventionsPatients received either clonidine (3 micrograms/kg, 15 min before induction) or placebo premedication for a sevoflurane-induced and sevoflurane-maintained anesthesia. Sevoflurane was titrated against a BIS held between 40 and 50. Analgesia was provided by local infiltration with bupivacaine. Need for postoperative analgesia was recorded.Results And ConclusionMean sevoflurane requirements were not lower with clonidine pretreatment. There was statistically better perioperative hemodynamic stability (i.e., fewer episodes of hypertension and tachycardia) without clinical relevance. A decreased need for postoperative analgesia was observed.

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