• Neurosurg. Clin. N. Am. · Oct 2011

    Multicenter Study Clinical Trial

    Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy.

    • Vikaas S Sohal and Felice T Sun.
    • Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94127, USA. vikaas.sohal@ucsf.edu
    • Neurosurg. Clin. N. Am. 2011 Oct 1;22(4):481-8, vi.

    AbstractDeep brain stimulation (DBS) is an established treatment for Parkinson's disease, and is increasingly used for other neuropsychiatric conditions including epilepsy. Nevertheless, neural mechanisms for DBS and other forms of neurostimulation remain elusive. The authors measured effects of responsive neurostimulation on intracranially recorded activity from participants in a clinical investigation to assess the safety of an implantable responsive neurostimulation system in epilepsy (RNS™ System, NeuroPace, Inc.). Neurostimulation acutely suppressed gamma frequency (35-100 Hz) phase-locking. This may represent a therapeutic mechanism by which responsive neurostimulation can suppress epileptiform activity and disconnect stimulated regions from downstream targets in epilepsy and other neuropsychiatric conditions.Copyright © 2011 Elsevier Inc. All rights reserved.

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