• Acta cirúrgica brasileira · Nov 2007

    Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation.

    • Angélica de Fátima de Assunção Braga, Derli Conceição Munoz, Franklin Sarmento da Silva Braga, Daniele Ribeiro de Araujo, Glória Maria Braga Potério, and Mario Mantovani.
    • Department of Anesthesiology, Faculty of Medical Sciences, UNICAMP, São Paulo, Brazil. franklinbraga@terra.com.br
    • Acta Cir Bras. 2007 Nov 1;22(6):446-50.

    PurposeTo evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm.MethodsDiaphragms were submitted to an indirect frequency stimulation of 0.1 and 1 Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2 microg/ml and rocuronium-4 microg/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker.ResultsThe decrease in twitch height was greater (p<0.01) with a frequency of 1 Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium.ConclusionThe frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for 1 Hz frequencies, at all periods studied.

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