• J Clin Anesth · Nov 2008

    Historical Article

    Liquor made quicker: alcohol as a synthetic reagent for molecules in anesthesia.

    • Keith Fragoza and Theodore A Alston.
    • Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
    • J Clin Anesth. 2008 Nov 1;20(7):556-9.

    AbstractEthanol was an early anesthetic, and chemists transformed it into better ones. Hypnotic/anesthetic/analgesic molecules prepared from ethanol include barbiturates, benzocaine, chloral hydrate, chloroform, diethyl ether, ethyl chloride, ethylene, etomidate, meperidine, paraldehyde, phenacetin, procaine, tribromoethanol, and urethane. Ethanol was sometimes mixed deliberately with the other anesthetics, and John Snow's inhaled amylene came from the "fusel oil" fraction of rotgut whisky.

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