• Donald R Taylor, Lynn R Webster, Steven Y Chun, Jeffrey Reinking, Mary Stegman, Steven Shoemaker, and Barry Fortner.
• Comprehensive Pain Care, Marietta, GA, Marietta, Georgia 30060, USA. dtaylor@cpcnopain.com
• Pain Med. 2007 Apr 1;8(3):281-8.

ObjectiveTo characterize breakthrough pain (BTP), its qualitative impact on quality of life (QoL), and the effects of BTP treatment on QoL.DesignMulticenter patient-reported survey.SettingFive pain treatment centers.PatientsFifty-six adults with chronic noncancer pain using oral transmucosal fentanyl citrate (OTFC, ACTIQ).ResultsForty-three patients qualified for in-depth analysis. BTP had a mean intensity of 9.0 (range 5-10) on an 11-point numerical scale (0 = no pain to 10 = worst possible pain), had a mean duration of 83 minutes, and had an adverse effect on multiple QoL domains. The largest negative QoL impacts were on "general activity level" and "ability to work." OTFC had a positive impact on both controlling BTP and improving QoL.ConclusionsBTP appears to be a clinically important condition in this population and is associated with an adverse impact on QoL. Understanding those QoL domains most affected by BTP and those potentially improved with treatment should help in developing quantitative QoL assessment tools and other outcome measures for BTP management studies.

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