• Nutrition · Mar 2016

    Profile of oxidative stress markers is dependent on vitamin D levels in patients with chronic hepatitis C.

    • Jorge P Sales de Almeida, Lucas Silva Liberatti, Fernanda Esteves Nascimento Barros, Ana Paula Kallaur, Marcell A Batisti Lozovoy, Bruna Miglioranza Scavuzzi, Carolina Panis, Edna Maria V Reiche, Isaias Dichi, and Andréa Name Colado Simão.
    • Department of Pathology, Clinical Analysis and Toxicology, Health Sciences Center, University of Londrina, Paraná, Brazil.
    • Nutrition. 2016 Mar 1; 32 (3): 362-7.

    ObjectivesAlthough vitamin D deficiency can change liver injury progression in patients with hepatitis C virus (HCV), the main molecular mechanisms involved are largely unknown. The first aim of this study was to evaluate the association between oxidative stress and hypovitaminosis D in patients with HCV. The second aim was to verify whether oxidative stress is involved in the molecular mechanisms related to liver injury.MethodsThe study included 147 participants: 89 controls and 58 patients with HCV (vitamin D < 30, n = 32; vitamin D > 30, n = 26).ResultsPatients with HCV and hypovitaminosis D presented significantly higher aminotransferase-to-platelet ratio index (APRI; P = 0.0464) and viral load (P = 0.0426) levels than patients with HCV without hypovitaminosis D. Regarding oxidative stress, HCV patients with hypovitaminosis D had higher advanced oxidation protein products (P = 0.0409), nitric oxide metabolites (P = 0.0206) levels, and oxidative stress index (P = 0.0196), whereas total radical-trapping antioxidant parameter (P = 0.0446) levels were significantly lower than HCV patients without hypovitaminosis D. Vitamin D in patients with HCV showed inverse correlations with levels of iron (r = -0.407, P = 0.0285), ferritin (r = -0.383, P = 0.0444), APRI (r = -0.453, P = 0.0154) and plasma lipid hydroperoxides levels (r = -0.426, P = 0.0189).ConclusionVitamin D insufficiency contributes to the inflammatory process and oxidative stress imbalance in patients with HCV. The profile of oxidative stress markers in these patients depends on vitamin D levels, which probably change intracellular signalling pathways and increase inflammation and liver injury.Copyright © 2016 Elsevier Inc. All rights reserved.

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