• J Clin Anesth · Feb 2014

    Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge.

    • Ailbhe M McDermott, Kah Hoong Chang, Kelly Mieske, Abdelaly Abeidi, Brian H Harte, Michael J Kerin, and Oliver J McAnena.
    • Discipline of Surgery, School of Medicine, National University of Ireland, Galway, Ireland. Electronic address: ailbhemcdermott@gmail.com.
    • J Clin Anesth. 2014 Feb 1;26(1):18-24.

    Study ObjectiveTo evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine.DesignPreliminary, prospective, nonrandomized study.SettingOperating room of a university hospital.Patients5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy.InterventionFive mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation.MeasurementsVenous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry.Main ResultsThe AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (Cmax) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels.ConclusionsThis preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.Copyright © 2014 Elsevier Inc. All rights reserved.

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