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- Mark J Heulitt, Shirley J Holt, Sterling Wilson, and Renée A Hall.
- Department of Pediatrics, University of Arkansas for Medical Science and Arkansas Children's Hospital, Little Rock AR 72202, USA. heulittmarkj@uams.edu
- Resp Care. 2003 Jul 1;48(7):689-96.
ObjectiveEvaluate the effects of continuous positive airway pressure (CPAP)/positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) on work of breathing (WOB).MethodsWith 13 anesthetized lambs we measured WOB with an esophageal balloon and flow signals. All the animals were sedated, intubated, and ventilated, using 2 pediatric ventilators (Servo 300 and VIP Bird). Ventilator settings were CPAP of 0, 5, and 10 cm H(2)O and PSV of 5 and 10 cm H(2)O with PEEP of 0, 5, and 10 cm H(2)O. Data were analyzed with 2-way analysis of variance.ResultsWith the Servo 300 the total WOB (WOB(T)) increased between CPAP/PEEP of 0 and 10 cm H(2)O (p ConclusionsWOB(T) increased as CPAP/PEEP was increased, and PSV lowered WOB(T.) We hypothesize that in a healthy animal model increased CPAP/PEEP may cause alveolar overdistention.
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