• Am J Geriatr Psychiatry · Jun 2005

    Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia.

    • Marci L Chew, Benoit H Mulsant, and Bruce G Pollock.
    • Western Psychiatric Institute and Clinic, 3811 O'Hara St., Pittsburgh, PA 15213, USA. mulsantbh@upmc.edu
    • Am J Geriatr Psychiatry. 2005 Jun 1;13(6):535-8.

    ObjectiveThe authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia.MethodsSAA and cognitive performance were assessed in 26 patients admitted to a geropsychiatric unit for the treatment of behavioral disturbances associated with dementia. SAA was measured by radioreceptor competitive binding assay. Cognition was tested with the Mini-Mental State Exam and the Severe Impairment Battery.ResultsHigher SAA was associated with lower cognitive performance.ConclusionThis study extends to patients with moderate-to-severe dementia the finding that higher SAA is associated with lower cognitive performance.

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