• Renal failure · Jan 2008

    Change in darbepoetin alfa administration schedule affects erythropoiesis-stimulating agent resistance in patients with chronic kidney disease receiving hemodialysis.

    • Manuel Molina, Maria Jose Navarro, Carmen de Gracia, Gracia Alvarez, Rosa de Alarcon, and Maria Angeles Garcia.
    • Hospital Universitario de Cartagena, Nefroclub Carthago, Cartagena, Spain.
    • Ren Fail. 2008 Jan 1;30(8):778-83.

    AbstractOne hundred and four patients receiving hemodialysis and undergoing anaemia treatment with darbepoetin alfa intravenously once weekly were switched to a biweekly dosing schedule and followed for 24 weeks. The darbepoetin alfa dose was adjusted to maintain the target Hb concentration of 11-14 g/dL. A significant decline in the erythropoiesis-stimulating agent resistance index was observed over the 24-week follow-up, beginning with week 16, whereas the mean dose of darbepoetin alfa did not change significantly after switching to the biweekly dosing schedule. Other factors that might affect resistance to erythropoiesis remained unchanged.

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