• Jacques E Chelly, Laura D Clark, Ralf E Gebhard, Robert M Raw, and Arthur Atchabahian.
• Department of Anesthesiology, University of Pittsburgh Medical Center (UPMC) Presbyterian-Shadyside Hospital, Pittsburgh, PA 15232, USA. Electronic address: chelje@anes.upmc.edu.
• J Clin Anesth. 2014 Feb 1;26(1):69-74.

AbstractEvidence supports the concept that patients undergoing major orthopedic surgery benefit from either thromboprophylaxis or peripheral nerve blocks, especially continuous techniques. A group of anesthesiologists with significant experience in orthopedic anesthesia and peripheral nerve blocks reviewed the literature related to thromboprophylaxis and peripheral nerve blocks and their combination in orthopedics. Major bleeding, including retroperitoneal hematoma, is an established complication of thromboprophylaxis. Major bleeding, including retroperitoneal hematoma, is also an established complication of peripheral nerve blocks. Between 1997 and 2012, only 4 case reports of major bleeding were reported in patients receiving thromboprophylaxis and peripheral nerve blocks. Evidence supports the safety of the combination of thromboprophylaxis and peripheral nerve blocks. This group of experts concluded that currently there is no evidence that the combination of thromboprophylaxis and peripheral nerve block increases the risk of major bleeding compared to either of the treatments alone.Copyright © 2014 Elsevier Inc. All rights reserved.

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