• Paediatric anaesthesia · Jan 1996

    Randomized Controlled Trial Comparative Study Clinical Trial

    Oral transmucosal ketamine: an effective premedication in children.

    • R Cioacă and I Canavea.
    • Department of Anaesthesiology, Oral and Maxillo-facial Surgery, University of Medicine, Bucharest, Romania.
    • Paediatr Anaesth. 1996 Jan 1;6(5):361-5.

    AbstractThe oral cavity offers a simple, painless way of drug administration. For this reason, we used oral transmucosal ketamine (5-6 mg.kg-1) for premedication in 25 children and compared it with intranasal ketamine (5-6 mg.kg-1), placebo and intramuscular ketamine (5-6 mg.kg-1). Oral transmucosal ketamine (OTK) provided effective sedation, facilitated i.v. line insertion and was accepted with pleasure by the patients (as lollipops). The lollipops produced a slight increase in gastric volumes but did not affect gastric pH. In conclusion OTK has been shown to be an effective, harmless preoperative medication in paediatric patients.

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