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Comparative Study
[Effect adrenaline and ephedrine against a background of aminazine on systemic, cerebral and extracerebral hemodynamics].
- S P Trofimenko, M D Gaevoĭ, A A Zaĭtsev, R V Mel'kumov, and M A Em.
- Farmakol Toksikol. 1978 May 1;41(3):299-302.
AbstractExperiments with anesthetized cats demonstrated chlorpromazine (2 mg/kg) to pervert the vasopressor action of adrenaline (5 mkg/kg) and ephedrine (2 mg/kg) on the systemic arterial pressure, cerebral and extracerebral tonicity of the vessels. The authors believe that with chlorpromazine pretreatment the adrenomimetics produce a selective stimulation of the beta-adrenergic receptors, this accounting for the observed depressor effect.
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