• T A Rummans, J M Evans, L E Krahn, and K C Fleming.
• Department of Psychiatry and Psychology, Mayo Clinic Rochester, Minnesota, USA.
• Mayo Clin. Proc. 1995 Oct 1;70(10):989-98.

ObjectiveTo review the evaluation and management of delirium in elderly patients for primary-care providers.DesignWe summarize the clinical features, course, pathophysiologic aspects, predisposing factors, causes, and differential diagnosis of delirium and discuss approaches to affected patients and various management strategies.ResultsDelirium, an altered mental state, occurs more frequently in elderly than in younger patients. The pathophysiologic changes associated with aging and the higher occurrence of multiple medical problems and need for medications contribute to the higher frequency of delirium in elderly patients. Evaluation should begin with a consideration of the most common causes, such as a change in or addition to prescribed medications, a withdrawal from alcohol or other sedative-hypnotic drugs, an infection, or a sudden change in neurologic, cardiac, pulmonary, or metabolic state. Finally, management of delirium is threefold: (1) identifying and treating underlying causes, (2) nonpharmacologic interventions, and (3) pharmacologic therapies to manage symptoms of delirium.ConclusionElderly patients frequently experience delirium. Delirious symptoms can produce devastating consequences if they are not recognized and appropriately treated.

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