• J. Neuroimmunol. · May 2012

    Comparative Study

    MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions.

    • Juliane Lescher, Franziska Paap, Verena Schultz, Laura Redenbach, Uta Scheidt, Hendrik Rosewich, Stefan Nessler, Eberhard Fuchs, Jutta Gärtner, Wolfgang Brück, and Andreas Junker.
    • Department of Neuropathology, University of Göttingen, Göttingen, Germany.
    • J. Neuroimmunol. 2012 May 15;246(1-2):27-33.

    AbstractHere we demonstrate that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles miRNA regulation in active human MS lesions. Detailed quantitative PCR analyses of the most up- and downregulated miRNAs of active human MS lesions in dissected lesions from marmoset EAE brains and inflamed spinal cords of EAE mice revealed that the conserved and highly regulated miRNAs, miRNA-155, miRNA-142-3p, miRNA-146a, miRNA-146b and miRNA-21, turned out to be similarly upregulated in marmoset and mouse EAE lesions.Copyright © 2012 Elsevier B.V. All rights reserved.

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