• Neuroscience letters · Aug 1996

    Clinical Trial

    Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.

    • M Schmelz and M Kress.
    • Department of Physiology and Experimental Pathophysiology, University of Erlangen-Nürnberg, Germany. schmelz@ipb.uni-erlangen.de
    • Neurosci. Lett. 1996 Aug 16;214(1):72-4.

    AbstractThe effect of acetylsalicylic acid (ASA) on capsaicin-evoked activation of cutaneous nociceptors was tested in a double blind study in 10 volunteers. Capsaicin (2% in ethanol) was applied topically for 30 min. Topical ASA (0.25 g/ml) reduced pain intensity and axon reflex flare size. Also, areas of secondary hyperalgesia to light touch and pin-prick were diminished. In contrast, capsaicin-induced heat hyperalgesia was unaffected by ASA. It is concluded that ASA counteracts the excitatory effects of capsaicin on nociceptors and mechanical hyperalgesia but not its sensitizing action to heat.

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