• Gen Thorac Cardiovasc Surg · Oct 2007

    Case Reports

    Successful treatment of sclerosing mediastinitis with a high serum IgG4 level.

    • Masaaki Inoue, Naohiro Nose, Hitoshi Nishikawa, Masaaki Takahashi, Yoh Zen, and Makoto Kawaguchi.
    • Department of Chest Surgery, Niigata Rosai Hospital, 1-7-12 Touncho, Joetsu, Niigata, Japan. mainoue@niirou.jp
    • Gen Thorac Cardiovasc Surg. 2007 Oct 1;55(10):431-3.

    AbstractSclerosing mediastinitis is not a common condition in the thoracic cavity and is difficult to cure. Several medications have been used; however, most of the cases do not achieve satisfactory results, and the most successful treatment is operative resection. We report the first case of IgG4-related sclerosing mediastinitis that showed IgG4-positive plasma cells infiltrated into the fibrous tissue and a high serum IgG4 level. The patient clearly showed remission of the symptoms after steroid therapy. Our findings suggest that the serum IgG4 level is a good selection indicator for steroid therapy in sclerosing mediastinitis.

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