• S C Kao, S D Adamson, L H Tatman, and K S Berbaum.
• Department of Radiology, 3894 JPP, The University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
• Pediatr Radiol. 1999 Apr 1;29(4):287-90.

BackgroundLimited information is available on post-discharge side effects of chloral hydrate sedation in pediatric imaging.ObjectiveTo prospectively study the post-discharge side effects of chloral hydrate sedation in pediatric CT and MR imaging.Materials And MethodsA total of 119 children undergoing CT and MRI were sedated using chloral hydrate with 89 % success (mean initial dose, 72 mg/kg body weight) and 98 % success after augmentation (mean total, 78 mg/kg body weight). The frequency of each post-discharge side effect was correlated with other side effects and 12 patient/technical parameters.ResultsThe survey was completed in 80 children. Sleepiness lasted for > 4 h in 28 %. Unsteadiness occurred in 68 % and hyperactivity in 29 %. Appetite became poor in 14 % and vomiting occurred in 15 %. Normal activity was resumed after > 4 h in 54 %. Sleep deprivation did not result in increased success or earlier onset of sedation and might be associated with hyperactivity. A higher dose did not result in an increased success rate or earlier onset of sedation within the dose range used in this study.ConclusionData on the post-discharge side effects of chloral hydrate sedation will be useful to radiologists, technologists, and nurses explaining to parents about sedation using this agent.

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