• Da-xin Sun, Yi-hua Zheng, Ai-xin Zhou, and Ming-pin Hu.
• Department of Anesthesiology, The people's Hospital of Jiangshan City, Jiangshan 324100, China.
• Zhonghua Yi Xue Za Zhi. 2008 Dec 9;88(45):3186-8.

ObjectiveTo investigate the best concentration ratio of propofol controlled-infusion combined with sevoflurane in anesthesia for patients undergoing laparoscopy.MethodsOne hundred patients undergoing cholecystectomy under laparoscopy were randomly divided into 5 equal groups treated with propofol controlled plasma at the concentrations of 1, 2, 3, 4, and 5 microg/ml respectively (Group 1-5). Bispectral index (BIS) was maintained at a range of 50 +/- 5 by adjusting sevoflurane inhalation. The end-tidal concentration of sevoflurane (ETsevo), systolic pressure, diastolic pressure, recovery time, awareness, and post-operative nausea and vomiting (PONV) within 24 h after operation were recorded. The best concentration ratio of propofol controlled-infusion combined with sevoflurane with the definition as the highest ETsevo without PONV decrease along with the increase of propofol concentration.ResultsETsevo was negatively correlated with and propofol concentration. There were nit significant differences in the systolic pressure, diastolic pressure, and recovery time among different groups. No incidence of intra-operative awareness was found. The PONV rates of Group 1 and 2 were both 60%, significantly higher than those of the other 3 groups (all P < 0.05) without significant differences in PONV rate among Group 3 - 5. The best concentration ratio of propofol controlled-infusion combined with sevoflurane was propofol controlled-infusion at the concentration of 1 microg/ml with ETsevo at the concentration as 1 minimal alveolar concentration (MAC).ConclusionPropofol controlled-infusion at the concentration of 1 microg/ml with ETsevo at the concentration as 1 MAC is the best concentration ratio with low PONV rate and a possibility to prevent intra-operative awareness.

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