• Deepak Talwar, Mayuri Johari, and Pallavi Periwal.
• Chest. 2014 Mar 1;145(3 Suppl):14A.

Session TitleAsthma PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: EBT is being researched as a biomarker for airway inflammation in Asthma with increased plateau temperature indicating exacerbation in asthmatics. But seasonal variation in plateau temperature and its slope in not reported. Aim of the study was to assess the seasonal variation in the kinetics of EBT in stable North Indian asthmatics where extremes of temperature exist between peak summers and winters.Methods14 stable patients(on constant dose of ICS and LABA) with Allergic Bronchial Asthma(BA) and 11 healthy volunteers were prospectively made to perform EBT using X-halo(Delmedica inc) during summer season(May-June) and again during winters(Dec- Jan) along with healthy volunteers. The ambient temperature in room was kept constant at around 20-25 degree Celsius in both the seasons. Paired sample t-test was used to check for seasonal variability on EBT in asthmatics and normal volunteers. Independent sample t-test was used to see the group variability. The significance level was kept at p<0.05.ResultsThere was significant increase (P=0.025) in the plateau temperature from recording in summer(32.05+/-2.04 degree Celsius) to that in winter(34.96+/-2.05 degree Celsius) in patient with BA. But there was no seasonal change in plateau temperature and slope in normal volunteers(31.29+/-1.95 degree Celsius in summers to 31.02+/-1.67 degree Celsius and 0.20+/-0.04 degree Celsius in summers to 0.18+/-0.05 degree Celsius in winters respectively P=0.382).ConclusionsThere was no significant seasonal variations in EBT in normal subjects. But, EBT in stable asthmatics showed rise during winters despite constant ambient temperature. This could be due to dynamic change in environment allergens. Hence, increase in EBT in asthmatics during winters need to be interpreted with caution.Clinical ImplicationsEBT is a marker of airway inflammation in asthmatics and may predict exacerbations especially during season change. Further studies are required to monitor EBT in allergic asthmas in all seasons before this can be used as biomarker of exacerbating asthma.DisclosureThe following authors have nothing to disclose: Mayuri Johari, Pallavi Periwal, Deepak TalwarNo Product/Research Disclosure Information.

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