• Chest · Mar 2014

    Sialic Acid value in pleural effusion as a diagnostic marker of malignancy.

    • Sherif Alsayed and Samar Marzouk.
    • Chest. 2014 Mar 1;145(3 Suppl):276A.

    Session TitlePleural Disease/Pleural Effusion PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The present study was designed to measure sialic acid levels in pleural effusion and serum samples of patients with malignant and nonmalignant diseases to discriminate each other, and to diagnose malignant effusion in a simple, cheap and reliable way.MethodsSixty patients with pleural effusion were enrolled in the study and classified into two groups, group (I) 30 patients with malignant pleural effusion, and group (II) 30 patients with nonmalignant pleural effusion. Pleural fluid (PF) and serum (S) levels of sialic acid were measured prior to any therapy; and PF/S sialic acid ratios were calculatedResultsPleural fluid and serum levels of sialic acid were significantly higher in malignant group compared to nonmalignant one. PF/S sialic acid ratio was higher in malignant group compared to nonmalignant group. In the malignant pleural effusion group, smokers showed a statistically significant higher pleural fluid and serum sialic acid levels as compared to nonsmokers. By using ROC curve, the cut off value of malignant pleural fluid sialic acid was 69.65 mg/dL, sensitivity was 70%, and specificity was 96%.ConclusionsThese findings can approve the value of pleural fluid sialic acid as a promising marker for diagnosis of malignant pleural effusion.Clinical ImplicationsDiaggnosis of malignant effusoinDisclosureThe following authors have nothing to disclose: Sherif Alsayed, Samar MarzoukNo Product/Research Disclosure Information.

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