• Yelda Varol, Ceyda Anar, Levent Usta, Gunseli Balci, and Rifat Ozcacar.
• Chest. 2014 Mar 1;145(3 Suppl):354A.

Session TitleCOPD Epidemiology & Physiology PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: COPD exacerbations are important and affects the course of the disease. Clinical trials showed that a subgroup of COPD patients had more exacerbations independent from their FEV1 values and thus a frequent exacerbation subgroup was defined. Small-airway damage has a role for the disease progression of COPD, but the exact relationship between small-airway damage and COPD exacerbations is not entirely clarified. In our study, we investigated the COPD patients who had frequent exacerbations in terms of small airway damage and their difference from patients who had not frequent exacerbations.Methods96 stable COPD patients between April 2011 and February 2012 were included in our study. If the patients had two or more exacerbation in the last year, they were defined as frequent exacerbators, if not they were defined as unfrequent exacerbators.ResultsThe mean FEV1 value of 51 frequent exacerbator was 880ml(34%). Their mean FVC was 1500 ml(45%), mean FEV1/FVC was 60 and mean FEF25-75 was 549 ml(17%). The mean FEV1, FVC, FEV1/FVC and FEF25-75 values of 45 unfrequent exacerbators were found as 1210ml(44%), 1780 ml(53%), 65 and 750 ml(25%) respectively. When we compared frequent and unfrequent exacerbators, statistical significance was found in FEF 25-75(p=0.009), FEF 25-75 %(p= 0.000), FEV1 ml(p=0.016), FEV1 %(p=0.007), FEV1/FVC(p=0.021) values. In addition, we found statistical significance only in FEF25-75 ml(p=0.015) and FEF 25-75 %(p=0.014) values between patients who were hospitalized in the last year because of COPD exacerbation or not.ConclusionsThe FEF25-75 values were found significantly low in frequent exacerbators and who hospitalized due to COPD exacerbations. However, additional comprehensive randomized trials dealing with small-airway obstruction and exacerbation frequency are essential.Clinical ImplicationsThe FEF25-75 values were found significantly low in frequent exacerbators and who hospitalized due to COPD exacerbations.DisclosureThe following authors have nothing to disclose: Yelda Varol, Ceyda Anar, Levent Usta, Gunseli Balci, Rifat OzcacarNo Product/Research Disclosure Information.

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