• Chest · Mar 2014

    NT-proBNP as Prognostic Biomarker in Patients With COPD Exacerbations and Respiratory Acidosis.

    • Enrique Zamora García, Elena Garcia Castillo, Tamara Alonso Pérez, Gonzalo Segrelles Calvo, Olga Rajas Naranjo, and Julio Ancochea.
    • Chest. 2014 Mar 1;145(3 Suppl):363A.

    Session TitleCOPD Epidemiology & Physiology PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The aim of our study was to evaluated the capacity of NT-proBNP to identify high risk patients with COPD exacerbations.MethodsPilot observational prospective study. We did the present study at the Hospital Universitario La Princesa (Madrid) in the period between 2012 may and 2013 may. We included 41 patients with COPD exacerbation and respiratory acidosis (pH<7,35 and PaCO2>45 mmHg) and needed of non-invasive mechanical ventilation. We did the following mesurements: 1.Clinical dates: spirometric values, previous COPD exacerbations, chronic oxygen therapy, comorbidities. 2.Laboratorie test. 3.NT-proBNP in the first 24th hours at the admission. 4.Complications during the income. 5.Death during the income. We classificated the patients into four groups according to the values of NT-proBNP: <500 pg/ml, 500-1.000 pg/ml, 1.000-5.000 pg/ml and >5.000 pg/ml.Results56% were men with about 76 years old. 25 patients had almost 2 exacerbations in the previous year. Patients with NT-proBNP>500 pg/ml had more probability of clinical complications during the income (more frequency cardiovascular one), more time of hospitalizations (13,3 vs 8,1 days), more death (7 vs 2), lower pH levels (7,26 vs 7,29) and higer PaCO2 levels (83,4 vs 70,6 mmHg).ConclusionsNT-proBNP was a good biomarker in patients with COPD exacerbation and could difference a high risk group.Clinical Implications1. Pre-selected a patients with poor prognostic. 2. Evaluated the implications of right ventricular function in the pathogenesis of the COPD exacerbation. 3. Evaluated news biomarkers in the COPD exacerbations.DisclosureThe following authors have nothing to disclose: Elena Garcia Castillo, Tamara Alonso Pérez, Gonzalo Segrelles Calvo, Olga Rajas Naranjo, Enrique Zamora García, Julio AncocheaNo Product/Research Disclosure Information.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…