• Daniel Coutinho, Inês Franco, Margarida Dias, Maria Tzer, and Maria Brito.
• Chest. 2014 Mar 1;145(3 Suppl):378A.

Session TitleCOPD PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The aim of our study was to look for the factors that affect survival of patients with COPD exacerbations admitted in a pulmonology department of a Portuguese central hospital.MethodsA retrospective nine-year study, where we included all the patients admitted with COPD exacerbations as a primary diagnosis between January 2004 and December 2012. Collected data included socio-demographic variables, smoking status and pack-years of smoking, pulmonary function tests, comorbidities and readmissions. Cox regression model was used to assess the influence of these variables on survival.ResultsThree hundred and sixty three patients were included. Mean age 70,7±10,4 years, 84,8% were men and mean FEV1 42,5%±16,8. The 30-day readmission rate was 9,9% and the one-year all-cause mortality rate was 24,2%. In univariate analysis, we found a significant relationship between overall survival and age (p<0,001), gender (p=0,007), length of hospital stay (p=0,008), FEV1 (p<0,001), DLCO (p<0,001), pCO2 (p<0,001), smoking status (p=0,016), obesity (p=0,029) and GOLD stage (p=0,002). We haven't found any relationship between pack-years of smoking, readmissions and some comorbidities, such as diabetes, hypertension and dyslipidemia. Ex-smoker status (p=0,001; HR=2,2) and increased GOLD stage (p=0,047; HR=1,5) had prognostic value on survival in our multivariate analysis.ConclusionsAmong patients admitted with COPD exacerbations, smoking status and GOLD stages were the main predictors of overall survival.Clinical ImplicationsDespite the new COPD risk classes, apparently in clinical practice smoking status and degree of airflow obstruction should still be considered as important predictors of survival.DisclosureThe following authors have nothing to disclose: Daniel Coutinho, Inês Franco, Margarida Dias, Maria Tzer, Maria BritoNo Product/Research Disclosure Information.

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