• J D Vertommen, H Van Aken, E Vandermeulen, M Vangerven, H Devlieger, A F Van Assche, and S M Shnider.
• Department of Anesthesiology, Katholieke Universiteit Leuven, Belgium.
• J Clin Anesth. 1991 Sep 1; 3 (5): 371-6.

Study ObjectiveTo determine the maternal and fetal effects of the addition of epidural sufentanil to 0.5% bupivacaine for cesarean delivery.DesignRandomized, double-blind, prospective study.SettingUniversity Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium.PatientsSixty women at term scheduled for elective cesarean section, all of whom had elected epidural anesthesia.InterventionsThe 60 women were divided into three groups of 20, with each group receiving a different 1 ml study solution: saline (control) or sufentanil 20 micrograms or sufentanil 30 micrograms added to 0.5% bupivacaine and epinephrine (1:200,000).Measurements And Main ResultsIn the mother, the quality of anesthesia, the duration of postoperative analgesia, the volume of anesthetic, and the frequency of side effects were examined. The neonates were evaluated at 5 and 10 minutes after birth by Apgar scores and between 60 and 120 minutes after birth by both the screening test developed by Prechtl and the Neurological and Adaptive Capacity Scoring System. Immediately after delivery, maternal and umbilical vein blood were drawn and assayed for sufentanil levels. Adding sufentanil significantly improved the quality of anesthesia without depressing the neurobehavioral status of the baby.ConclusionThe epidural injection of sufentanil added to 0.5% bupivacaine with epinephrine improved the quality of anesthesia during elective cesarean section without jeopardizing the safety of the baby.

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