• Francesco De Blasio, Maria Grazia Santaniello, Giulia Miracco Berlingieri, Barbara Bellofiore, and Luca Scalfi.
• Chest. 2014 Mar 1;145(3 Suppl):468A.

Session TitlePulmonary Function TestingSESSION TYPE: Slide PresentationsPRESENTED ON: Sunday, March 23, 2014 at 04:15 PM - 05:15 PMPURPOSE: According to the predominant phenotype, patients suffering from Chronic Obstructive Pulmonary Oisease (COPO) may present varying and important nutritional profile alterations, up to extreme degrees of severe proteic-energetic malnutrition. In our study, Bioelectricallmpedance Analysis (BIA) has been used in the evaluation of nutritional status (with particular regards to body lean mass alterations) of patients suffering from COPDMETHODS: Up to now, 68 patients (46 M; mean age 70.6 yrs) affected by stable mild to very severe COPD (GOLD 2011 stages l-IV) were evaluated. All of them underwent body plethysmographic evaluation of pulmonary function, six-minute walking test (6MWT) and respiratory muscles strength evaluation (with maximum Inspiratory and expiratory pressures - MIP/MEP - assessment). Moreover, BIA variables were studied with Dietosystem Human Scan, that expresses either quantitative (BIA index) and qualitative (multifrequency relation and phase angle) body lean mass alterations. Furthermore, SIA data from a control age matched group were collected.ResultsAs compared to healthy controls, all BIA variables related to qualitative variations of either body lean mass and skeletal muscles of patients suffering from COPD were significantly impaired. Similar modifications were recorded with handgrip measurements, with strong correlation among BIA variables and handgrip measurements. Furthermore, we have recorded a statistically significant correlation (p<0.001) between BIA variables and Vital Capacity, Inspiratory Capacity, FEV1, MIP, MEP and walked distance at 6MWT.ConclusionsPreliminary data from this study underline the close correlation between BIA variables, muscular function (both skeletal and respiratory) and pulmonary function. A potential speciific usefulness of BIA as well as handgrip measurement seems to be recommended in the global evaluation of patients suffering from COPD.Clinical ImplicationsPatients suffering from COPD studied with BIA could be effectively differentiated and received more adequate treatment.DisclosureThe following authors have nothing to disclose: Francesco De Blasio, Maria Grazia Santaniello, Francesca De Blasio, Giulia Miracco Berlingieri, Barbara Bellofiore, Luca ScalfiNo Product/Research Disclosure Information.

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