• Sagrario Mayoralas Alises, Patricia Lazo Meneses, Carolina Gotera, Jonathan Cámara Fernández, Salvador Diaz Lobato, Eva Mañas Baena, Paola Arrieta Narvaez, Carolina Jurkojc Mohremberger, and Patricia Castro Acosta.
• Chest. 2014 Mar 1;145(3 Suppl):554A.

Session TitleNon-Invasive VentilationSESSION TYPE: Slide PresentationsPRESENTED ON: Saturday, March 22, 2014 at 12:15 PM - 01:15 PMPURPOSE: Introduction We know the role of non-invasive ventilation (NIV) in the prevention of respiratory complications in high-risk patients who undergo ERCP.MethodsWe propose a randomized controlled study in 37 consecutive patients who underwent ERCP and considered high risk, according to present at least one of the following criteria: age> 70 years, BMI> 35, NYHA II-IV CHF, heart disease ischemic or COPD. A total of 21 patients received O2 and 16 received noninvasive ventilation by nasal mask. Arterial blood gases were performed before and immediately after ERCP. APACHE score was obtained from the patients. Propofol was administered until a sedation level 3-4 on the Ramsay scale,ResultsBoth groups were homogeneous. The post-ERCP PCO2 was lower (p = 0.001) and post ERCP pH was greater (p = 0.001) in the group of patients with NIV. In multivariate analysis adjusting for gender, APACHE score, pH, PCO2 pre-ERCP, age, propofol dose and duration of the procedure, these differences remained significant. (pCO2 difference = 5.54, 95% CI = 2.3-8.7, pH difference = 0.047, 95% CI = 0013-0081). There were 4 complications, one in the NIV group (hypotension) and 3 in the O2 group (two cardiac arrhythmias and gastrointestinal bleeding).ConclusionsIn high-risk patients who undergo ERCP, NIV prevents the appearence of hypercapnia and respiratory acidosis.Clinical ImplicationsEndoscopic retrograde cholangiopancreatography (ERCP) with sedation and analgesia performed by well-trained endoscopists has proved to be a safe procedure, although significant complications may occur as a result of instrumentation or due to the effects of sedation and analgesia. These complications are more frequent when patients are deeply sedated, undergo complex or prolonged explorations, or undergo therapeutic procedures. Respiratory complications are very important in high risk patients. Respiratory insufficiency and clinical hypoventilation are common during the realization of ERCP for patients with hypoventilation risk factors such as the elderly, patients with cardiopathy, patients with a history of respiratory failure, patients who are morbidly obese, and patients with obesity-hypoventilation syndrome. The purpose of our study is to assess whether NIV can prevent ventilatory alterations during ERCP in patients with risk factors associated with the development of hypoventilation.DisclosureThe following authors have nothing to disclose: Patricia Lazo Meneses, Salvador Diaz Lobato, Sagrario Mayoralas Alises, Jonathan Cámara Fernández, Patricia Castro Acosta, Paola Arrieta Narvaez, Carolina Gotera, Carolina Jurkojc Mohremberger, Eva Mañas BaenaNo Product/Research Disclosure Information.

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