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Acta Pharmacol. Sin. · Aug 2004
Polymorphism of Prodynorphin promoter is associated with schizophrenia in Chinese population.
- Chang-Shun Zhang, Zheng Tan, Lan Lu, Sheng-Nan Wu, Ying He, Niu-Fan Gu, Guo-Yin Feng, and Lin He.
- Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China.
- Acta Pharmacol. Sin. 2004 Aug 1;25(8):1022-6.
AimTo investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia.MethodsSNPs in the promoter and exon regions of PDYN were screened and genotyped for association study in a cohort of Chinese Han schizophrenia cases and controls.ResultsTwo SNPs PDYN-1576C>T and PDYN-946C>G were identified in the promoter region but PDYN-946C>G showed significant differences of allele distribution (x2=6.15, P=0.013) and genotype distribution (x2=6.87, P=0.032) between schizophrenic and control subjects.ConclusionPDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia.
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