• Virginia Almadana, Teodoro Montemayor, Estefania Luque, Ana Gomez-Bastero, and Soledad Montserrat.
• Chest. 2014 Mar 1;145(3 Suppl):610A.

Session TitleTobacco Cessation and Prevention PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: To analyze and validate 2 month treatment programs, as well as the real dose and time decided by the patient regarding what is recommended and its influence on the tobacco cessation rate.MethodsA prospective study including all the patients who attended our tobacco cessation program during the last 6 months. We analyzed several variables: epidemiological, dependence questionnaires, motivation and anxiety/depression questionnaires; cooximetry, recommended dose (varenicline (V): 0.5/1mgrs for 2 months; bupropion (B) only 150 mgrs/day for 2 months), real dose and duration of the treatment, tobacco cessation rates after 3 and 6 months and causes of early abandonment of medication.ResultsWe included 312 patients: 175 were treated with V (56%) and 137 with B (44%). By comparing both groups, we couldn't find differences regarding tobacco cessation rate after 3 (V: 64.4% / B: 67.2%) or 6 months (V: 64.2% / B: 67.2%). We realized the patients followed the recommended dose (82.3% with V and 94.2% with B, p=0.001). Cessation rates after 6 months in patients who fulfil the treatment were 53.6% with V and 59% with B). Regarding the duration of treatment: V:6.6±1.6 vs 3.3±1.4 weeks and B:7.9±0.7 vs 3.3±1.8 weeks, p<0.001. As for cessation rates after 6 months: V: 96% vs 51.2%; B: 95.7% vs 6.8%; p<0.001. The most frequent causes of early medication abandonment were economic reasons, psycological dependence and fasle self-control on abstinence symptoms.Conclusions1. Using 2 month treatments with both varenicline and half the recommended dose of bupropion, cessation rates are very good >64%. 2. Below 5 week treatments are clearly insufficient with bupropion as well as varenicline (worse). 3. Causes of early abandonment of medication were mainly due to economic reasons, psychological dependence and false self-control.Clinical ImplicationsTo improve adherence to tobacco cessation treatment and decreasing early medication abandonment and side effects.DisclosureThe following authors have nothing to disclose: Ana Gomez-Bastero, Concepcion Romero, Estefania Luque, Virginia Almadana, Soledad Montserrat, Teodoro MontemayorNo Product/Research Disclosure Information.

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