• André de Sá Braga Oliveira, Lívia Bandeira Costa, Thiago de Oliveira Assis, Diógenes Luís da Mota, Eduardo Ériko Tenório de França, José Cândido de Araújo Filho, Silvania Tavares Paz Rosas, and Paloma Lys de Medeiros.
• Integrated Colleges of Patos, Brazil. andre.sboliveira@gmail.com
• Acta Cir Bras. 2012 Feb 1;27(2):109-16.

PurposeThe objective of this study was to analyze the effects of Pressure Controlled Ventilation mode (PCV-C) and PSV mode in diaphragm muscle of rats.MethodsWistar rats (n=18) were randomly assigned to the control group or to receive 6 hours of PCV and PSV. After this period, animals were euthanized and their diaphragms were excised, frozen in liquid nitrogen and stored in at -80º C for further histomorphometric analysis.ResultsResults showed a 15% decrease in cross-sectional area of muscle fibers on the PCV-C group when compared to the control group (p<0.001) and by 10% when compared to the PSV group (p<0.05). Minor diameter was decreased in PCV-C group by 9% when compared with the control group (p<0.001) and by 6% when compared to the PSV group (p<0.05). When myonuclear area was analyzed, a 16% decrease was observed in the PCV-C group when compared to the PSV group (p<0.05). No significant difference between the groups was observed in myonuclear perimeter (p>0.05).ConclusionShort-term controlled mechanical ventilation seems to lead to muscular atrophy in diaphragm fibers. The PSV mode may attenuate the effects of VIDD.

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