• Esmaeil Idani.
• Chest. 2014 Mar 1;145(3 Suppl):6A.

Session TitleAsthma PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The sensitivity of impulse oscillometry (IOS) to reflect different aspects of airway obstruction in obese men after intensive challenge has not been comprehensively appreciated. In obese subjects evaluated with spirometry we need more sensitive devices to assess exercise-related restrictive and obstructive abnormalities that hinder an exercise program for obese men who are going to be engaged in such programs. The objective was to measure airway responses following room temperature exercise challenge in healthy obese young men.Methods14 obese participants (BMI > 35) with well-preserved FEV1/FVC ratio underwent an exercise bronchial provocation test (EBPT). The results were compared to data obtained from control group including 10 non-asthmatic lean (BMI < 25) men. IOS and spirometry measurements were collected at baseline and for 20 minutes after challenge at 5-min intervals. All subjects completed a recommended-8-minutes-running on treadmill. Exercise intensity was verified based on Heart rate and Kilojoules of workload. For obese individuals, the equation (HRpeak=200-0.5×Age) was used.ResultsCorrelations were found between resting FEV1 and IOS, except for the area of reactance (Ax) in obese group. IOS and spirometry identified significant differences in respiratory resistance between two groups (p<0.05). Spirometry revealed significant differences in post-challenge percent changes only at 5 minutes after exercise; however IOS identified significant differences in respiratory resistance at 5 and 10-min post-challenge time points. The sensitivity for R5 was significantly greater than for R20 in obese group (p<0.05).ConclusionsIOS parameters especially X at 5Hz and Ax maybe more sensitive for respiratory resistance evaluation in obese men after exercise challenge. IOS detected differences in degree of response in obese group more than that was detected by spirometry.Clinical ImplicationsWe recommend therefore that appropriate pulmonary function testing is required when fitness experts need subjecting obese individual to exercise programs. In the case of obese subjects, due to their unique conditions, IOS diagnosis may be more reliable than spirometry.DisclosureThe following authors have nothing to disclose: Mustafa Moradi, Esmaeil IdaniNo Product/Research Disclosure Information.

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