• Jamie S McConnell, Sandeep Shewale, Niall A Munro, Kalpesh Shah, Angela H Deakin, and Andrew W G Kinninmonth.
• Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, England HA7 4LP, United Kingdom. jsm@doctors.net.uk
• Knee. 2012 Aug 1;19(4):295-8.

AbstractA prospective, randomised controlled trial compared the effects of two medications intended to reduce blood loss from total knee arthroplasty. Patients were randomised to one of the following three treatment groups: 10mg/kg tranexamic acid at given at induction of anaesthesia, 10 ml of fibrin spray administered topically during surgery, or to a control group receiving neither treatment. Sixty six patients underwent elective cemented total knee arthroplasty; computer navigation was used in all cases. There was no significant difference in blood loss between the tranexamic acid and fibrin spray groups (p=0.181). There was no significant difference in blood loss between the tranexamic acid and fibrin spray groups(p=0.181). The fibrin spray led to a significant reduction in blood loss compared to control (p=0.007). The effect of tranexamic acid did not reach significance (p=0.173). We conclude that fibrin spray was effective in reducing blood loss but that with a study of this power, we were unable to detect an effect of tranexamic acid in cemented navigated total knee replacement at the dose used.Copyright © 2011 Elsevier B.V. All rights reserved.

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