• Raul Galera, Rodolfo Alvarez-Sala, David Romero, Carlos Villasante, Carlos Carpio, and Francisco García-Río.
• Chest. 2014 Mar 1;145(3 Suppl):13A.

Session TitleAsthma PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: to compare the perception of dyspnea (POD) during cycle exercise testing and airway challenge to adenosine in non-asmathic (group 1) fictitious asthmatic (group 2), and asthmatic (group 3) obese subjects.Methodsfictitious asthma was considered when patients have used bronchodilator or corticoid inhaler medication during the last year despite not having a positive bronchial responsiveness testing or elevation of exhaled nitric oxide (NO). Anxiety and depression questionnaires (State-Trait Anxiety Inventory for Adults [STAI] and Beck Depression Inventory [Beck], respectively), body impedance assessment, exhaled NO, spirometry and body plethysmography measurements were performed in all patients. POD was measured in both, adenosine challenge and cycle ergometer testing, using the modified 10-point Borg scale. Finally, incremental exercise testing was conducted on an electronically cycle ergometer (Oxycon Alpha, Viasys).Resultswe included 73 patients (group 1=27, group 2=22, group 3=24). Groups were not different by demographic (age, sex, smoking habit) and anthropometric variables. Group 2 had higher Trait anxiety scoring than group 1 (30.9±13.8 vs.19.1±13.4, p<0.05). Pulmonary function testing were similar between groups 1 and 2. During adenosine challenge, POD assessed by the rate of change in Borg score was greater in group 2 than in group 1 (1.95±1.66 vs. 0.57±1.12, p<0.05). Also, relationship between adenosine concentration and changes of the Borg score was greater in group 2 than in group 1 (p=0,051). Likewise, in the exercise testing, the intercept (but not the slope) for work intensity-Borg ratings was significantly lower in group 2 and 3 than in group 1 (13.7±11.6; 12.5±6.7; 30.6±10.8, p<0.001, respectively). Finally, fictitious asthmatic patients had lower intercept and higher slope for oxygen uptake-Borg rating than non-asthmatic patients (p<0.001).Conclusionsin obese patients, POD during exercise testing is greater in fictitious asthmatic than in non-asthmatic subjects but similar to asthmatic patients. Also, perceptual response to bronchoconstriction is higher in fictitious asthma than in non-asthma patients.Clinical Implicationsoverdiagnosis of asthma in obese subjects could be due to a greater PODDISCLOSURE: The following authors have nothing to disclose: Carlos Carpio, Francisco García-Río, David Romero, Isabel Fernández, Raul Galera, Carlos Villasante, Rodolfo Álvarez-SalaNo Product/Research Disclosure Information.

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