• Z Liu, H Qin, Z Yang, Y Xia, W Liu, J Yang, Y Jiang, H Zhang, Y Wang, and Q Zheng.
• Department of Surgery, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, China.
• Aliment. Pharmacol. Ther. 2011 Jan 1;33(1):50-63.

BackgroundInfection following abdominal operation remains a major factor affecting the morbidity of patients after surgery.AimTo determine the effects of perioperative administration of probiotics on the gut barrier function and the surgical outcome in patients undergoing elective colorectal surgery.MethodsOne hundred patients with colorectal carcinoma were randomly divided into the control group (n = 50) and the probiotics group (n = 50). The probiotics were given orally for 6 days preoperatively and 10 days post-operatively. Outcomes were measured by bacterial translocation, gut permeability, the effect on the faecal microbiota, and the clinical outcomes such as infectious-related complications and gut defecation function.ResultsCompared with the control group, probiotics group had increased transepithelial resistance (P < 0.05), reduced transmucosal permeation of horseradish peroxidase and lactulose/mannitol ratio, reduced bacterial translocation (P < 0.05), decreased ileal-bile acid binding protein (P < 0.05) and positive rate of blood bacterial DNA (P < 0.05) and an enhanced mucosal tight junction protein expression. They had decreased blood enteropathogenic bacteria and increased faecal bacterial variety. The post-operative recovery of peristalsis, incidence of diarrhoea, and infectious-related complications were also improved.ConclusionProbiotics can improve the integrity of gut mucosal barrier by benefiting the faecal microbiota, and decreasing infectious complications in patients with colorectal cancer undergoing colorectomy.© 2010 Blackwell Publishing Ltd.

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