• Med. J. Aust. · Aug 1983

    Response of the box-jellyfish (Chironex fleckeri) cardiotoxin to intravenous administration of verapamil.

    • J W Burnett and G J Calton.
    • Med. J. Aust. 1983 Aug 20;2(4):192-4.

    AbstractVerapamil, a calcium antagonist, has been shown to be effective in delaying death in mice after intravenous challenge with box-jellyfish (Chironex fleckeri) venom. Death from a challenge of up to three mouse-lethal doses of venom was significantly delayed after the prior intravenous administration of verapamil (P = 0.003). A smaller dose of verapamil could "rescue" mice previously envenomed with 1.25 mouse-lethal doses (P = 0.0001). These data suggest that verapamil injections should be added to the first-aid procedures performed on the beach for victims of box-jellyfish stings.

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