• Anticancer research · Jul 2004

    Serum levels of S-100B protein and neuron-specific enolase in glioma patients: a pilot study.

    • Maaike J Vos, Tjeerd J Postma, Frans Martens, Bernard M J Uitdehaag, Marines A Blankenstein, W Peter Vandertop, Ben J Slotman, and Jan J Heimans.
    • Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands. MJ.Vos@vumc.nl
    • Anticancer Res. 2004 Jul 1;24(4):2511-4.

    BackgroundSerum levels of S-100B protein (S-100B) and neuron-specific enolase (NSE) are elevated after various cerebral injuries and are considered markers of central nervous system damage. In brain tumor patients, literature data on the prognostic value of serum S-100(B) and NSE levels are scarse and conflicting.Patients And MethodsWe assessed serum S-100B and NSE levels in 20 consecutive cerebral glioma patients, and evaluated serum levels in relation to survival to determine their prognostic value. Kaplan-Meier survival curves were constructed for patients with "high" (> median value) versus "low" (< or = median value) serum S-100B and NSE levels.ResultsA statistically significant shorter survival was found in patients with high serum S-100B levels, whereas a similar classification of patients based on serum NSE levels demonstrated no statistically significant difference in survival between the two groups.ConclusionThese preliminary data suggest that serum S-100B might be a prognostic variable in cerebral glioma patients. Further study is warranted to evaluate whether serum S-100B is an additional, independent prognostic variable.

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