• Ann Fr Anesth Reanim · Jun 2010

    Review

    [Lipid emulsions for the treatment of systemic local anesthetic toxicity: Efficacy and limits].

    • A G M Aya, J Ripart, M-A Sebbane, and J-E de La Coussaye.
    • Département d'anesthésie-douleur, pôle anesthésie-réanimation-douleur-urgences, GHU de Caremeau, Nîmes, France. guy.aya@chu-nimes.fr
    • Ann Fr Anesth Reanim. 2010 Jun 1;29(6):464-9.

    AbstractLocal anaesthetic toxicity always results from rapid and important increase in their plasma concentrations. Clinically, neurologic and cardiovascular symptoms may occur, especially life-threatening cardiac arrhythmias and cardiac depression. Resuscitating patients from cardiac toxicity was known as difficult, until the introduction of lipid emulsion therapy. From experimental data, at least two mechanisms of action can be proposed, a sink-effect and an improvement of cardiomyocyte metabolism. The present article is a mini-review of the current use of lipid emulsions for the treatment of local anaesthetic cardiac toxicity. The mechanisms of cardiac toxicity and those of lipid emulsion therapy are summarized, and the clinical experience of this therapy and its limits are presented.2010 Elsevier Masson SAS. All rights reserved.

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