• Int J Clin Pharm Th · Jan 2002

    Case Reports

    Phenytoin toxicity with mandibular tremor secondary to intravenous administration.

    • D Türkdogan, F Onat, U Türe, and N Pamir.
    • Institute of Neurological Sciences, University of Marmara, Maltepe, Istanbul, Turkey.
    • Int J Clin Pharm Th. 2002 Jan 1;40(1):18-9.

    AbstractThe parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients.

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