Phenytoin toxicity with mandibular tremor secondary to

Int J Clin Pharm Th · Jan 2002

Case Reports

Phenytoin toxicity with mandibular tremor secondary to intravenous administration.

The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients.

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- D Türkdogan, F Onat, U Türe, and N Pamir.
- Institute of Neurological Sciences, University of Marmara, Maltepe, Istanbul, Turkey.
- Int J Clin Pharm Th. 2002 Jan 1;40(1):18-9.
AbstractThe parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients.

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Phenytoin toxicity with mandibular tremor secondary to intravenous administration.

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