-
- P Narcy, G Zorza, A M Taburet, J M Mersch, D Devictor, and G Huault.
- Département de Pédiatrie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
- Arch. Fr. Pediatr. 1990 Oct 1;47(8):591-3.
AbstractA severe poisoning with intravenous phenytoin in a newborn was treated with peritoneal dialysis in spite of its reported poor effectiveness, the drug being 90% protein-bound. During 10 hours, 1.41 mg/hr were eliminated by biotransformation and 1.80 mg/hr were removed with peritoneal dialysis allowing to suppress quickly life threatening cardiac side effects. This efficacy may be explained by an increase in the unbound protein fraction and a diffusion speed through the peritoneum higher than in older patients.
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