Archives françaises de pédiatrie
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The authors studied the hospital mortality among 0-15 years old children hospitalized in a department of pediatrics in Tunis from 1983 to 1987. A significant decrease in the mortality rate was observed (from 12.21 to 8.23%). ⋯ The maximum of deaths were observed during the Summer-Autumn period and especially in the evenings. The decrease in the mortality rate was correlated with the time when mothers began to be hospitalized with their children.
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A severe poisoning with intravenous phenytoin in a newborn was treated with peritoneal dialysis in spite of its reported poor effectiveness, the drug being 90% protein-bound. During 10 hours, 1.41 mg/hr were eliminated by biotransformation and 1.80 mg/hr were removed with peritoneal dialysis allowing to suppress quickly life threatening cardiac side effects. This efficacy may be explained by an increase in the unbound protein fraction and a diffusion speed through the peritoneum higher than in older patients.