• Quirino Lai, Alfonso W Avolio, Jan Lerut, Gurusharan Singh, See Ching Chan, Pasquale B Berloco, Giuseppe Tisone, Salvatore Agnes, Kenneth S Chok, William Sharr, Massimo Rossi, Tommaso M Manzia, and Chung Mau Lo.
• Department of General Surgery and Organ Transplantation, Sapienza University, Umberto I Hospital, Rome, Italy. lai.quirino@libero.it
• J. Hepatol. 2012 Nov 1;57(5):974-9.

Background & AimsGreater tumor aggressiveness and different management modalities of hepatocellular cancer (HCC) before liver transplantation (LT) may explain the higher recurrence rates reported in Asia. This study investigates the prognostic factors for HCC recurrence in a Western and an Eastern HCC patient cohort in order to analyze the respective roles of tumor- and management-related factors on the incidence of post-LT HCC recurrence.MethodsData of 273 HCC patients, transplanted during the period January 1999-March 2009, were obtained from the Rome Inter-University Liver Transplant Consortium (n=157) and Hong Kong University (n=116) databases. Median follow-up was 4.3 years (range: 0.2-12). Recurrence rate and multivariate logistic regression analysis was performed on the entire population and on Milan criteria-in (MC-in) patients.ResultsMultivariate analysis on the entire population identified four independent risk factors for post-LT HCC recurrence: microvascular invasion (odds ratio, OR=4.88; p=0.001), poor tumor grading (OR=6.86; p=0.002), diameter of the largest tumor (OR=4.72; p=0.05), and previous liver resection (LR) (OR=3.34; p=0.04). After removal of LR, only tumor-related variables were independent risk factors for recurrence. When only MC-in patients were analyzed, no difference was observed between the two cohorts in terms of recurrence rate after LR patient removal.ConclusionsLR followed by salvage "for HCC recurrence" LT represents the main reason for a higher HCC recurrence rate in the Hong Kong patients, but not LR followed by salvage "for liver failure" LT in the Roman group. This approach towards HCC before LT may not be universally applicable. The precise patient background must be taken into account in order to identify the best pre-LT strategy.Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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