• Kim Papp, Alan Menter, Bruce Strober, Greg Kricorian, Elizabeth H Z Thompson, Cassandra E Milmont, Ajay Nirula, and Paul Klekotka.
• Probity Medical Research, Waterloo, Ontario, Canada.
• J. Am. Acad. Dermatol. 2015 Mar 1;72(3):436-439.e1.

BackgroundNovel therapies are needed for difficult-to-treat populations of patients with psoriasis.ObjectiveWe sought to assess the efficacy and safety of the interleukin-17 Receptor A inhibitor brodalumab in patients with psoriasis with or without a self-reported history of psoriatic arthritis (PsA) and with or without a history of biologic use.MethodsSubset analyses of a phase II, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis were performed. Improvement from baseline in Psoriasis Area and Severity Index score of 75%, 90%, and 100% at week 12; static Physician Global Assessment (0/1) score; Dermatology Life Quality Index response; and Psoriasis Symptom Inventory response were evaluated within subgroups.ResultsEfficacy and quality-of-life measures were generally similar between subgroups of patients with or without a history of PsA and with or without a history of biologic use across brodalumab doses and were significantly higher among patients who received brodalumab 140 mg every 2 weeks or 210 mg every 2 weeks versus placebo.LimitationsDifferences between subgroups were not compared statistically, PsA was self-reported, only skin involvement/symptoms were reported, and reasons for discontinuation of prior biologic were not captured.ConclusionBrodalumab is efficacious in patients with psoriasis with or without a history of PsA or biologic use.Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

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